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编 号：F761298
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规格
价格
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1mg
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5mg
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CAS No: 905703-97-1
产品详情
生物活性：
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.
体内研究：
Ganitumab (AMG 479; 1 mg/剂; i.p; Na?ve 和荷瘤小鼠) 抑制 IGF1 诱导的小鼠肺中 mIGF1R 的激活。Ganitumab (300 μg/剂; i.p.; 雌性无胸腺裸鼠) 减少外周血中性粒细胞。Ganitumab (300 μg/剂; i.p.;雄性无胸腺裸鼠) 导致雄性小鼠糖耐量受损，并增加血清中 mGH，mIGF1 和 mIGFBP3。Animal Model:Na?ve and tumor-bearing mice
Dosage:1 mg/dose
Administration:Intraperitoneal injection
Result:Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.
Animal Model:Male athymic nude mice
Dosage:300 μg/dose
Administration:Intraperitoneal injection, twice per week for a total of five doses
Result:Had significantly higher serum glucose levels than hIgG1-pretreated mice.Increased serum levels of mIGF1, mIGFPB3 and mGH.
Animal Model:Female athymic nude mice
Dosage:300 μg/dose
Administration:Intraperitoneal injection, twice per week for a total of five doses
Result:Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
体外研究：
Ganitumab (AMG 479; 0.032-500 nM; 10 分钟; CT26 细胞) 结合 mIGF1R 并抑制 IGF1 和 IGF2 介导的 mIGF1R 的激活。
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.
体内研究：
Ganitumab (AMG 479; 1 mg/剂; i.p; Na?ve 和荷瘤小鼠) 抑制 IGF1 诱导的小鼠肺中 mIGF1R 的激活。Ganitumab (300 μg/剂; i.p.; 雌性无胸腺裸鼠) 减少外周血中性粒细胞。Ganitumab (300 μg/剂; i.p.;雄性无胸腺裸鼠) 导致雄性小鼠糖耐量受损，并增加血清中 mGH，mIGF1 和 mIGFBP3。Animal Model:Na?ve and tumor-bearing mice
Dosage:1 mg/dose
Administration:Intraperitoneal injection
Result:Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.
Animal Model:Male athymic nude mice
Dosage:300 μg/dose
Administration:Intraperitoneal injection, twice per week for a total of five doses
Result:Had significantly higher serum glucose levels than hIgG1-pretreated mice.Increased serum levels of mIGF1, mIGFPB3 and mGH.
Animal Model:Female athymic nude mice
Dosage:300 μg/dose
Administration:Intraperitoneal injection, twice per week for a total of five doses
Result:Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
体外研究：
Ganitumab (AMG 479; 0.032-500 nM; 10 分钟; CT26 细胞) 结合 mIGF1R 并抑制 IGF1 和 IGF2 介导的 mIGF1R 的激活。
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