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编 号：F761294
分子式：C20H19N5OS
分子量：377.46
分子式：C20H19N5OS
分子量：377.46
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CAS No: 904815-29-8
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生物活性：
Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI50?value of 0.15?mM. Anticancer agent 83 reduces?mitochondrial membrane potential?and induces DNA damage to induces leukemia cells apoptosis.
体外研究：
Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human?colon carcinoma?HCT116 p53?/? cells with deletion of?P53?gene (GI50=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI50=7.4 μM), human?ovarian carcinoma?Skov 3?cells (GI50=10 μM), and human chronic myelogenous leukemia K562?cells (GI50=5.4 μM).Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases?mitochondrial membrane potential.
Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI50?value of 0.15?mM. Anticancer agent 83 reduces?mitochondrial membrane potential?and induces DNA damage to induces leukemia cells apoptosis.
体外研究：
Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human?colon carcinoma?HCT116 p53?/? cells with deletion of?P53?gene (GI50=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI50=7.4 μM), human?ovarian carcinoma?Skov 3?cells (GI50=10 μM), and human chronic myelogenous leukemia K562?cells (GI50=5.4 μM).Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases?mitochondrial membrane potential.
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