产品
编 号：F761195
分子式：C20H17N5O2S3
分子量：455.58
分子式：C20H17N5O2S3
分子量：455.58
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 892742-76-6
产品详情
生物活性：
UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
体内研究：
UT-B-IN-1 (300 μg；腹腔注射，1 次) 在自由取水和进食的小鼠中，增加排尿量并降低尿液渗透性。Animal Model:Male mice (wild-type or UT-B knockout)
Dosage:300 μg
Administration:Intraperitoneal injection, 300 μg, once
Result:Reduced urine osmolality and urea concentration in wild-type mice with V2-receptor agonist dDAVP injection. Increased urine volume and reduced urine osmolality and urea concentration in mice with free access to food and water but without dDAVP.
体外研究：
UT-B-IN-1 (1-1000 nM) 抑制尿素预载红细胞的尿素外排，IC50 值为 26.7 nM。UT-B-IN-1 抑制 AQP1-null 红细胞的水运输。UT-B-IN-1 (0-10 μM；24 h) 对 MDCK 细胞无细胞毒性。
UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
体内研究：
UT-B-IN-1 (300 μg；腹腔注射，1 次) 在自由取水和进食的小鼠中，增加排尿量并降低尿液渗透性。Animal Model:Male mice (wild-type or UT-B knockout)
Dosage:300 μg
Administration:Intraperitoneal injection, 300 μg, once
Result:Reduced urine osmolality and urea concentration in wild-type mice with V2-receptor agonist dDAVP injection. Increased urine volume and reduced urine osmolality and urea concentration in mice with free access to food and water but without dDAVP.
体外研究：
UT-B-IN-1 (1-1000 nM) 抑制尿素预载红细胞的尿素外排，IC50 值为 26.7 nM。UT-B-IN-1 抑制 AQP1-null 红细胞的水运输。UT-B-IN-1 (0-10 μM；24 h) 对 MDCK 细胞无细胞毒性。
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