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编 号：F761181
分子式：C20H21NO4
分子量：339.39
分子式：C20H21NO4
分子量：339.39
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CAS No: 890984-26-6
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生物活性：
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.
体内研究：
Curcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) 改善 HFD (高脂肪饮食) 诱导的肥胖小鼠的胰岛素抵抗和肝脂肪变性。Animal Model:6-week-old males, 20 g, C57BL/6 mice
Dosage:100 mg/kg
Administration:Diet; daily for 13 weeks
Result:Significantly suppressed the increases in the insulin level and HOMA-IR.
体外研究：
Curcumin 5-8 (20 μM; 24 h) 降低 AML12 细胞中 PA (palmitic acid (HY-N0830)) 诱导的 SREBP1 表达水平并增加 Bcl2/BAX 表达。
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity.
体内研究：
Curcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) 改善 HFD (高脂肪饮食) 诱导的肥胖小鼠的胰岛素抵抗和肝脂肪变性。Animal Model:6-week-old males, 20 g, C57BL/6 mice
Dosage:100 mg/kg
Administration:Diet; daily for 13 weeks
Result:Significantly suppressed the increases in the insulin level and HOMA-IR.
体外研究：
Curcumin 5-8 (20 μM; 24 h) 降低 AML12 细胞中 PA (palmitic acid (HY-N0830)) 诱导的 SREBP1 表达水平并增加 Bcl2/BAX 表达。
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