产品
编 号：F761179
分子式：C28H22ClNO4
分子量：471.93
分子式：C28H22ClNO4
分子量：471.93
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 890808-56-7
产品详情
生物活性：
M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer.
体内研究：
M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6?J mice and p53 gene knockout C57BL/6?J mice) selectively reduces the half-life of CRY1 and is well tolerated with a good pharmacokinetic profile in vivo and enhances apoptosis.Animal Model:C57BL/6?J mice and p53 gene knockout C57BL/6?J mice
Dosage:5, 50, 300 and 1000 mg/kg
Administration:intraperitoneal injection, daily, for 5 days
Result:Prolonged the life span of p53 gene knockout mice.
体外研究：
M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc cells) reduces the half-life of CRY1 in a dose-dependent manner and causes circadian changes.M47 (10 μM; 24-44 h; U2OS cells) decreases the level of CRY1 in U2OS cells.
M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer.
体内研究：
M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6?J mice and p53 gene knockout C57BL/6?J mice) selectively reduces the half-life of CRY1 and is well tolerated with a good pharmacokinetic profile in vivo and enhances apoptosis.Animal Model:C57BL/6?J mice and p53 gene knockout C57BL/6?J mice
Dosage:5, 50, 300 and 1000 mg/kg
Administration:intraperitoneal injection, daily, for 5 days
Result:Prolonged the life span of p53 gene knockout mice.
体外研究：
M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc cells) reduces the half-life of CRY1 in a dose-dependent manner and causes circadian changes.M47 (10 μM; 24-44 h; U2OS cells) decreases the level of CRY1 in U2OS cells.
产品资料
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