产品
编 号:F761150
分子式:C18H13FN6OS
分子量:380.4
产品类型
结构图
CAS No: 887349-03-3
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生物活性:
Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis.
体外研究:
Anticancer agent 110 (化合物 3d) (0.01 μM-100 μM) 抑制白血病 K-562 细胞,IC50 为 0.7 μM。Anticancer agent 110 (70 nM、700 nM;24 h) 在 K-562 细胞中引起更高水平的 DNA 损伤。Anticancer agent 110 (70 nM、700 nM;24 h) 诱导白血病细胞形态发生促凋亡变化。