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编 号：F761148
分子式：C89H137N23O25S
分子量：1961.24
分子式：C89H137N23O25S
分子量：1961.24
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是否有货
1mg
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5mg
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10mg
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CAS No: 887255-16-5
产品详情
生物活性：
LQVTDSGLYRCVIYHPP (LP17) is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP can get access into brain and block TREM-1.
体内研究：
LQVTDSGLYRCVIYHPP (LP17) (0.5 或 1 mg/kg；鼻内；每天一次，持续 3 天) 减轻小鼠缺血诱导的梗塞和神经元损伤。Animal Model:Adult male C57BL/6J mice (20-25?g), mice cerebral ischemia/reperfusion (I/R) model induced by middle cerebral artery occlusion (MCAO)
Dosage:0.5?mg/kg or 1?mg/kg
Administration:Intranasal administration, once daily for 3 consecutive days after MCAO
Result:Abolished ischemia-induced TREM-1 elevation at 1?mg/kg. Significantly reduced infarct volume by 27.3%, induced a markedly reduction in TUNEL positive cells and FJC positive neurons at 1?mg/kg. Rescued neurological deficits and cognitive dysfunction of MCAO mice. Inhibited microglial M1 polarization and neutrophil infiltration.
体外研究：
LQVTDSGLYRCVIYHPP (LP17) (1 或 10 μM；24 小时) 显著降低再氧合后促炎细胞因子和趋化因子的 mRNA 水平，并显著降低小胶质细胞氧-葡萄糖剥夺 (OGD) 中 IL-1β 和 IL-18 的细胞外蛋白水平模型。 LQVTDSGLYRCVIYHPP (LP17) (10 μM；24 小时) 与小胶质细胞 SYK 相互作用。
LQVTDSGLYRCVIYHPP (LP17) is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP can get access into brain and block TREM-1.
体内研究：
LQVTDSGLYRCVIYHPP (LP17) (0.5 或 1 mg/kg；鼻内；每天一次，持续 3 天) 减轻小鼠缺血诱导的梗塞和神经元损伤。Animal Model:Adult male C57BL/6J mice (20-25?g), mice cerebral ischemia/reperfusion (I/R) model induced by middle cerebral artery occlusion (MCAO)
Dosage:0.5?mg/kg or 1?mg/kg
Administration:Intranasal administration, once daily for 3 consecutive days after MCAO
Result:Abolished ischemia-induced TREM-1 elevation at 1?mg/kg. Significantly reduced infarct volume by 27.3%, induced a markedly reduction in TUNEL positive cells and FJC positive neurons at 1?mg/kg. Rescued neurological deficits and cognitive dysfunction of MCAO mice. Inhibited microglial M1 polarization and neutrophil infiltration.
体外研究：
LQVTDSGLYRCVIYHPP (LP17) (1 或 10 μM；24 小时) 显著降低再氧合后促炎细胞因子和趋化因子的 mRNA 水平，并显著降低小胶质细胞氧-葡萄糖剥夺 (OGD) 中 IL-1β 和 IL-18 的细胞外蛋白水平模型。 LQVTDSGLYRCVIYHPP (LP17) (10 μM；24 小时) 与小胶质细胞 SYK 相互作用。
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