产品
编 号：F761137
分子式：C133H216N44O38
分子量：3039.41
分子式：C133H216N44O38
分子量：3039.41
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CAS No: 88650-17-3
产品详情
生物活性：
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS).
体内研究：
FX06 (2.4 mg/kg, i.v. bolus) shows significantly improved pulmonary and circulatory function in a pig model of hemorrhagic shock and reperfusion.FX06 (2.4 mg/kg, i.p., twice daily) improves survival and reduces capillary leak in mice with Dengue-induced shock.FX06 (3.6 mg/kg, i.v.) protects mice from Ischemia/reperfusion (I/R)-induced kidney injury by aiding in epithelial cell proliferation and tissue repair.Animal Model:Pig model of hemorrhagic shock and reperfusion
Dosage:2.4 mg/kg
Administration:Intravenous injection (i.v.) bolus
Result:Reduced raccumulation of myeloperoxidase-pos. cells (mainly neutrophils) in myocardium, liver, and small intestine, and reduced interleukin-6 plasma levels.
Animal Model:Mice with Dengue-induced shock
Dosage:2.4 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly improved survival rates, reduced capillary leak within lungs and the intestine, and reduced hemoconcentration and fibrinogen consumption.
体外研究：
FX-06 (50 μM, 3 days) inhibits the production of D2HGin HEK-293T cells transfected with IDH1 R132H.
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS).
体内研究：
FX06 (2.4 mg/kg, i.v. bolus) shows significantly improved pulmonary and circulatory function in a pig model of hemorrhagic shock and reperfusion.FX06 (2.4 mg/kg, i.p., twice daily) improves survival and reduces capillary leak in mice with Dengue-induced shock.FX06 (3.6 mg/kg, i.v.) protects mice from Ischemia/reperfusion (I/R)-induced kidney injury by aiding in epithelial cell proliferation and tissue repair.Animal Model:Pig model of hemorrhagic shock and reperfusion
Dosage:2.4 mg/kg
Administration:Intravenous injection (i.v.) bolus
Result:Reduced raccumulation of myeloperoxidase-pos. cells (mainly neutrophils) in myocardium, liver, and small intestine, and reduced interleukin-6 plasma levels.
Animal Model:Mice with Dengue-induced shock
Dosage:2.4 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly improved survival rates, reduced capillary leak within lungs and the intestine, and reduced hemoconcentration and fibrinogen consumption.
体外研究：
FX-06 (50 μM, 3 days) inhibits the production of D2HGin HEK-293T cells transfected with IDH1 R132H.
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