产品
编 号：F761072
分子式：C200H312N62O57S6
分子量：4689.39
分子式：C200H312N62O57S6
分子量：4689.39
产品类型
规格
价格
是否有货
100μg
询价
询价
结构图
CAS No: 880107-52-8
产品详情
生物活性：
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease.
体内研究：
Psalmotoxin 1 (icv，1 ng/kg，单次剂量) 通过直接抑制 ASIC1a 在有意识的中风模型中发挥神经保护作用。Psalmotoxin 1 (尾静脉注射，10 ng/kg，每日一次，持续 7 天) 抑制乳腺癌小鼠模型的肿瘤生长。Animal Model:Male spontaneously hypertensive rats (SHR)
Dosage:1 ng/kg, a single dose.
Administration:Intracerebroventricular (i.c.v.) injection
Result:Reduced cortical and striatal infarct volumes measured 72 h post-stroke.Reduced the severity of motor deficit at 1 and 3 days after stroke compared to control rats. Displayed an anti-apoptotic effect in the occluded hemisphere (reduced stroke-induced caspase-3 positive cells).
Animal Model:Female nude BALB/C mice (orthotopic implantation, MCF-7 and MDA-MB-231 cells)
Dosage:10 ng/kg, daily for 7 days.
Administration:Tail vein injection
Result:Inhibited breast tumor growth.
体外研究：
Psalmotoxin 1 (20 nM，125 s) 通过显著改变稳态脱敏曲线以降低 H+ 浓度来抑制 ASIC1a 电流。Psalmotoxin 1 (30 nM) 与 Ca2+ 竞争结合 ASIC1a 通道。 Psalmotoxin 1 (100 或 200 ng，24-72 小时) 显著减弱 MCF-7 和 MDA-MB-231 细胞的迁移、增殖和侵袭。 Psalmotoxin 1 (100 ng/mL，24 h) 显著抑制酸诱导的增加参与细胞内钙和 LDH 释放，诱导髓核细胞 (NPC) 细胞凋亡和细胞周期停滞。
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease.
体内研究：
Psalmotoxin 1 (icv，1 ng/kg，单次剂量) 通过直接抑制 ASIC1a 在有意识的中风模型中发挥神经保护作用。Psalmotoxin 1 (尾静脉注射，10 ng/kg，每日一次，持续 7 天) 抑制乳腺癌小鼠模型的肿瘤生长。Animal Model:Male spontaneously hypertensive rats (SHR)
Dosage:1 ng/kg, a single dose.
Administration:Intracerebroventricular (i.c.v.) injection
Result:Reduced cortical and striatal infarct volumes measured 72 h post-stroke.Reduced the severity of motor deficit at 1 and 3 days after stroke compared to control rats. Displayed an anti-apoptotic effect in the occluded hemisphere (reduced stroke-induced caspase-3 positive cells).
Animal Model:Female nude BALB/C mice (orthotopic implantation, MCF-7 and MDA-MB-231 cells)
Dosage:10 ng/kg, daily for 7 days.
Administration:Tail vein injection
Result:Inhibited breast tumor growth.
体外研究：
Psalmotoxin 1 (20 nM，125 s) 通过显著改变稳态脱敏曲线以降低 H+ 浓度来抑制 ASIC1a 电流。Psalmotoxin 1 (30 nM) 与 Ca2+ 竞争结合 ASIC1a 通道。 Psalmotoxin 1 (100 或 200 ng，24-72 小时) 显著减弱 MCF-7 和 MDA-MB-231 细胞的迁移、增殖和侵袭。 Psalmotoxin 1 (100 ng/mL，24 h) 显著抑制酸诱导的增加参与细胞内钙和 LDH 释放，诱导髓核细胞 (NPC) 细胞凋亡和细胞周期停滞。
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