产品
编 号：F760961
分子式：C34H22O8
分子量：558.53
分子式：C34H22O8
分子量：558.53
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 87084-99-9
产品详情
生物活性：
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
体内研究：
Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长。Animal Model:EX-3LL tumor-bearing mice
Dosage:50 mg/kg, 100 mg/kg
Administration:IP; once daily for 21 days
Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
体外研究：
Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力。Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡。Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活。
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
体内研究：
Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长。Animal Model:EX-3LL tumor-bearing mice
Dosage:50 mg/kg, 100 mg/kg
Administration:IP; once daily for 21 days
Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
体外研究：
Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力。Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡。Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活。
产品资料
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