产品
编 号：F083814
分子式：C19H22ClNO
分子量：315.84
分子式：C19H22ClNO
分子量：315.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
400
In-stock
5g
968
In-stock
10g
1399
In-stock
结构图
CAS No: 1229-29-4
产品详情
生物活性：
Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant.. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system.. Doxepin has also been proposed as a protective factor against oxidative stress..
体内研究：
Doxepin Hydrochloride (多塞平1mg/kg和5mg/kg腹腔注射，每天1次，持续21天) 对Aβ1-42诱导的大鼠记忆障碍有保护作用。 .Animal Model:SD male rats.
Dosage:1, 5mg/kg
Administration:Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result:Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.
体外研究：
多塞平的保护作用与通过PI3K/AKT/mTOR信号通路增强PSD-95和突触蛋白1的表达有关。。
Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant.. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system.. Doxepin has also been proposed as a protective factor against oxidative stress..
体内研究：
Doxepin Hydrochloride (多塞平1mg/kg和5mg/kg腹腔注射，每天1次，持续21天) 对Aβ1-42诱导的大鼠记忆障碍有保护作用。 .Animal Model:SD male rats.
Dosage:1, 5mg/kg
Administration:Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result:Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.
体外研究：
多塞平的保护作用与通过PI3K/AKT/mTOR信号通路增强PSD-95和突触蛋白1的表达有关。。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备