产品
编 号：F760733
分子式：C17H10BrClN4O
分子量：401.64
分子式：C17H10BrClN4O
分子量：401.64
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CAS No: 853725-86-7
产品详情
生物活性：
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively.
体外研究：
Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine (HY-13685) (IC50=7.8976 μM).Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1.Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM.
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively.
体外研究：
Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine (HY-13685) (IC50=7.8976 μM).Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1.Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM.
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