产品
编 号：F760703
分子式：C21H22N8O3S
分子量：466.52
分子式：C21H22N8O3S
分子量：466.52
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 851471-44-8
产品详情
生物活性：
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.
体内研究：
Anti-inflammatory agent 49 (10 mg/kg，每 8 小时一次，持续 72 小时）可治疗小鼠 LPS 诱导的内毒素血症。Animal Model:Female BALB/c AnNCrl micee (Strain Code 028)
Dosage:LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h)
Administration:Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.
Result:Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .Dramatically reduced the occurrence of critical symptoms such as respiratory distress.
体外研究：
1.Anti-inflammatory agent 49 降低LPS (HY-D1056) 诱导的H9c2 细胞线粒体功能障碍，可拯救 LPS 诱导的小鼠内毒素血症。2.Anti-inflammatory agent 49 可抑制LPS 处理后Drp1 的产生及Drp1- fis1 的相互作用。
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.
体内研究：
Anti-inflammatory agent 49 (10 mg/kg，每 8 小时一次，持续 72 小时）可治疗小鼠 LPS 诱导的内毒素血症。Animal Model:Female BALB/c AnNCrl micee (Strain Code 028)
Dosage:LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h)
Administration:Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.
Result:Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .Dramatically reduced the occurrence of critical symptoms such as respiratory distress.
体外研究：
1.Anti-inflammatory agent 49 降低LPS (HY-D1056) 诱导的H9c2 细胞线粒体功能障碍，可拯救 LPS 诱导的小鼠内毒素血症。2.Anti-inflammatory agent 49 可抑制LPS 处理后Drp1 的产生及Drp1- fis1 的相互作用。
产品资料
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