产品
编 号：F083793
分子式：C31H40ClN7O8S2
分子量：738.27
分子式：C31H40ClN7O8S2
分子量：738.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1229194-11-9
产品详情
生物活性：
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban monohydrate (0.5、2.5 和 12.5 mg/kg；口服；一次) 显著且剂量依赖性地减少血栓形成并延长 PT。Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban monohydrate (1、1 和 5 分钟) 以浓度依赖性方式延长人血浆的 PT、TT 和 APTT。Edoxaban monohydrate 抑制凝血酶诱导的血小板聚集，IC50 值为 2.90 μM。
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban monohydrate (0.5、2.5 和 12.5 mg/kg；口服；一次) 显著且剂量依赖性地减少血栓形成并延长 PT。Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban monohydrate (1、1 和 5 分钟) 以浓度依赖性方式延长人血浆的 PT、TT 和 APTT。Edoxaban monohydrate 抑制凝血酶诱导的血小板聚集，IC50 值为 2.90 μM。
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