产品
编 号：F760677
分子式：C19H21FN2O2
分子量：328.38
分子式：C19H21FN2O2
分子量：328.38
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CAS No: 849909-77-9
产品详情
生物活性：
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
体内研究：
MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%).Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats.CompoundRoute Dose (mg/kg) Cmax (ng/mL)AUCt (ng·h/mL)T1/2 (h)Vss (h)Cl (mL/min/kg)F (%)
D0iv18093470.371.1147.1/
po51632841.27//16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o..Animal Model:SD rats
Dosage:1, 5 mg/kg
Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:Showed oral bioavailability in rats (F=16.3%).
体外研究：
MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively.
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
体内研究：
MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%).Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats.CompoundRoute Dose (mg/kg) Cmax (ng/mL)AUCt (ng·h/mL)T1/2 (h)Vss (h)Cl (mL/min/kg)F (%)
D0iv18093470.371.1147.1/
po51632841.27//16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o..Animal Model:SD rats
Dosage:1, 5 mg/kg
Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:Showed oral bioavailability in rats (F=16.3%).
体外研究：
MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively.
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