产品
编 号：F760627
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是否有货
1mg
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CAS No: 845264-92-8
产品详情
生物活性：
Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease.
体内研究：
Atacicept (TACI-Ig; 100 μg; i.p.; 每周三次，共 14 天; BALB/c 小鼠) 降低正常小鼠成熟 B 细胞计数和血清抗体水平。Atacicept (100 μg; i.p.; 每周三次，共 21 天) 抑制胶原诱导性关节炎 (CIA) 小鼠模型的疾病进展和自身抗体滴度。Animal Model:Male DBA/1 mice with CIA models
Dosage:100 μg
Administration:intraperitoneal injection; three times of week for 21 days
Result:Increased serum titers of anti-collagen Abs and few overt signs of disease.
Animal Model:BALB/c mice
Dosage:100 μg
Administration:intraperitoneal injection; three times of week for 14 days
Result:Reduced mature B cell populations but had little effect on other cell lineages.Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.Decerased the serum levels of IgM about 2.3-fold.
Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease.
体内研究：
Atacicept (TACI-Ig; 100 μg; i.p.; 每周三次，共 14 天; BALB/c 小鼠) 降低正常小鼠成熟 B 细胞计数和血清抗体水平。Atacicept (100 μg; i.p.; 每周三次，共 21 天) 抑制胶原诱导性关节炎 (CIA) 小鼠模型的疾病进展和自身抗体滴度。Animal Model:Male DBA/1 mice with CIA models
Dosage:100 μg
Administration:intraperitoneal injection; three times of week for 21 days
Result:Increased serum titers of anti-collagen Abs and few overt signs of disease.
Animal Model:BALB/c mice
Dosage:100 μg
Administration:intraperitoneal injection; three times of week for 14 days
Result:Reduced mature B cell populations but had little effect on other cell lineages.Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.Decerased the serum levels of IgM about 2.3-fold.
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