产品
编 号：F760609
分子式：C19H19NO4
分子量：325.36
分子式：C19H19NO4
分子量：325.36
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结构图
CAS No: 84212-49-7
产品详情
生物活性：
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC50 of 0.1674?μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ1-42 aggregation (self-, Cu2+-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has?the?potential?for?Alzheimer' disease (AD)?research.
体外研究：
AChE/BuChE-IN-1 (Compound 1)?is mixed-type inhibitor of competitive inhibition and non-competitive inhibition that can simultaneously bind to CAS and PAS of the AChE and BuChE enzyme. AChE/BuChE-IN-1 has no significant inhibitory effect in the ·DPPH scavenging assay (IC50>500 μM). AChE/BuChE-IN-1 selectively chelates Cu2+, Fe2+, Zn2+ and Al3+ ions, while had no chelating ability to other biometals.
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC50 of 0.1674?μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ1-42 aggregation (self-, Cu2+-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has?the?potential?for?Alzheimer' disease (AD)?research.
体外研究：
AChE/BuChE-IN-1 (Compound 1)?is mixed-type inhibitor of competitive inhibition and non-competitive inhibition that can simultaneously bind to CAS and PAS of the AChE and BuChE enzyme. AChE/BuChE-IN-1 has no significant inhibitory effect in the ·DPPH scavenging assay (IC50>500 μM). AChE/BuChE-IN-1 selectively chelates Cu2+, Fe2+, Zn2+ and Al3+ ions, while had no chelating ability to other biometals.
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