产品
编 号：F083751
分子式：C20H26N2O4
分子量：358.43
分子式：C20H26N2O4
分子量：358.43
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CAS No: 122898-67-3
产品详情
生物活性：
Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
体内研究：
Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.
体外研究：
Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.
Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
体内研究：
Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.
体外研究：
Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.
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