产品
编 号：F083707
分子式：C20H27ClN2O4
分子量：394.89
分子式：C20H27ClN2O4
分子量：394.89
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
720
In-stock
1g
1040
In-stock
5g
2724
In-stock
结构图
CAS No: 122892-31-3
产品详情
生物活性：
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
体内研究：
Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.Animal Model:Male ddY-strain mice (23.7-28.5 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration
Result:Accelerated gastric emptying at 30 mg/kg dose.
Animal Model:Male ddY-strain mice (23.7-28.5 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:Cmax (358 ‰), T1/2 (24.9 min) at 30 mg/kg dose.
体外研究：
Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
体内研究：
Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.Animal Model:Male ddY-strain mice (23.7-28.5 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration
Result:Accelerated gastric emptying at 30 mg/kg dose.
Animal Model:Male ddY-strain mice (23.7-28.5 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:Cmax (358 ‰), T1/2 (24.9 min) at 30 mg/kg dose.
体外研究：
Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.
产品资料
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