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编 号：F760513
分子式：C254H416N72O75S10
分子量：5999.09
分子式：C254H416N72O75S10
分子量：5999.09
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CAS No: 820211-82-3
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生物活性：
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease.
体内研究：
Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O2 mice.Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice.Animal Model:Mice, treated with Mechanical ventilation with O2-rich gas
Dosage:1 mg/kg
Administration:Intranasal inhalation
Result:Increased the lung abundance of nuclear Klf4 protein.
Animal Model:Su/Hx rat model
Dosage:0.2 mg/kg
Administration:Subcutaneous injection (s.c.), daily for 2 weeks.
Result:Reduced elastase activity and reversed pulmonary hypertension.
体外研究：
Tiprelestat (4 and 8 μM) inhibits P. aeruginosa-secreted peptidase.Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells.Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells.
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease.
体内研究：
Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O2 mice.Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice.Animal Model:Mice, treated with Mechanical ventilation with O2-rich gas
Dosage:1 mg/kg
Administration:Intranasal inhalation
Result:Increased the lung abundance of nuclear Klf4 protein.
Animal Model:Su/Hx rat model
Dosage:0.2 mg/kg
Administration:Subcutaneous injection (s.c.), daily for 2 weeks.
Result:Reduced elastase activity and reversed pulmonary hypertension.
体外研究：
Tiprelestat (4 and 8 μM) inhibits P. aeruginosa-secreted peptidase.Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells.Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells.
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