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编 号：F760352
分子式：C30H40O9
分子量：544.63
分子式：C30H40O9
分子量：544.63
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CAS No: 791117-61-8
产品详情
生物活性：
Physachenolide C is a potent and selective BET inhibitor that induces apoptosis and arrests the cell cycle in the G0-G1 phase, with antitumor activity.
体内研究：
Physachenolide C (20 mg/kg IT daily for 15 doses) significantly inhibits tumour growth and caused complete tumour regression in a mouse model of melanoma, with no significant toxic effects in mice. Also, tumours treated with Physachenolide C shows a significant increase in the percentage of TUNEL-positive cells (40%).
体外研究：
Physachenolide C (0.01-10 μM, 48 h) inhibits Yale University Mouse Melanoma (YUMM) cell lines YUMM2.1 and YUMMER1.7 with the IC50 values of 0.5159 μM and 1.8230 μM, respectively and results in a significant increase in early apoptotic cells, causing cells to stagnate in the G0-G1 phase.
Physachenolide C is a potent and selective BET inhibitor that induces apoptosis and arrests the cell cycle in the G0-G1 phase, with antitumor activity.
体内研究：
Physachenolide C (20 mg/kg IT daily for 15 doses) significantly inhibits tumour growth and caused complete tumour regression in a mouse model of melanoma, with no significant toxic effects in mice. Also, tumours treated with Physachenolide C shows a significant increase in the percentage of TUNEL-positive cells (40%).
体外研究：
Physachenolide C (0.01-10 μM, 48 h) inhibits Yale University Mouse Melanoma (YUMM) cell lines YUMM2.1 and YUMMER1.7 with the IC50 values of 0.5159 μM and 1.8230 μM, respectively and results in a significant increase in early apoptotic cells, causing cells to stagnate in the G0-G1 phase.
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