产品
编 号：F083405
分子式：C26H26ClF6NO5
分子量：581.93
分子式：C26H26ClF6NO5
分子量：581.93
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CAS No: 1228580-11-7
产品详情
生物活性：
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.
体内研究：
ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival.ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time.Animal Model:ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively.
Dosage:0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration:Orally once daily for 14 days.
Result:Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.
体内研究：
ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival.ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time.Animal Model:ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively.
Dosage:0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration:Orally once daily for 14 days.
Result:Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
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