产品
编 号：F760052
分子式：C20H22N4OS
分子量：366.48
分子式：C20H22N4OS
分子量：366.48
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CAS No: 744206-31-3
产品详情
生物活性：
SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 μM and 1.579 μM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease.
体内研究：
SD-6 (100、300 和 500 mg/kg；口服；单剂量) 对未怀孕的雌性 Wistar 大鼠没有毒性作用。SD-6 (2.5、5 和 10 mg/kg；口服；一天 3 次，持续 7 天) 改善了东莨菪碱 (HY-N0296) 诱导的雄性 Wistar 大鼠认知和记忆缺陷。SD-6 (2.5、5 和 10 mg/kg；口服；单剂量) 显著改善了大鼠中东莨菪碱诱导的异常，促进生化指标正常化。Animal Model:10–11 weeks nonpregnant female Wistar rats (220–280 g).
Dosage:100, 300 and 500 mg/kg.
Administration:Oral gavage; single dose.
Result:Showed safety and tolerability.
Animal Model:10–11 weeks male Wistar rats (220–280 g).
Dosage:2.5、5、10 mg/kg.
Administration:Oral gavage; 3 times a day for 7 days or single dose.
Result:Had the function of repairing cognitive and memory deficits.Reduced the level of AChE and malonaldehyde (MDA), increased the level of acetylcholine, superoxide dismutase (SOD), glutathione (GSH) and catalase.
体外研究：
SD-6 (5-80 μM；24 h) 在 SH-SY5Y 细胞中具有神经保护作用。
SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 μM and 1.579 μM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease.
体内研究：
SD-6 (100、300 和 500 mg/kg；口服；单剂量) 对未怀孕的雌性 Wistar 大鼠没有毒性作用。SD-6 (2.5、5 和 10 mg/kg；口服；一天 3 次，持续 7 天) 改善了东莨菪碱 (HY-N0296) 诱导的雄性 Wistar 大鼠认知和记忆缺陷。SD-6 (2.5、5 和 10 mg/kg；口服；单剂量) 显著改善了大鼠中东莨菪碱诱导的异常，促进生化指标正常化。Animal Model:10–11 weeks nonpregnant female Wistar rats (220–280 g).
Dosage:100, 300 and 500 mg/kg.
Administration:Oral gavage; single dose.
Result:Showed safety and tolerability.
Animal Model:10–11 weeks male Wistar rats (220–280 g).
Dosage:2.5、5、10 mg/kg.
Administration:Oral gavage; 3 times a day for 7 days or single dose.
Result:Had the function of repairing cognitive and memory deficits.Reduced the level of AChE and malonaldehyde (MDA), increased the level of acetylcholine, superoxide dismutase (SOD), glutathione (GSH) and catalase.
体外研究：
SD-6 (5-80 μM；24 h) 在 SH-SY5Y 细胞中具有神经保护作用。
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