产品
编 号：F760045
分子式：C22H38O5
分子量：382.53
分子式：C22H38O5
分子量：382.53
产品类型
规格
价格
是否有货
结构图
CAS No: 742104-91-2
产品详情
生物活性：
JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases.
体外研究：
Munc13-1 是二酰甘油第二信使途径的靶标，在胞吐作用期间的囊泡成熟中发挥作用。通过在囊泡融合之前作用于突触囊泡启动来参与神经递质释放，并参与易释放囊泡池 (RRP) 的活性依赖性再填充。
JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases.
体外研究：
Munc13-1 是二酰甘油第二信使途径的靶标，在胞吐作用期间的囊泡成熟中发挥作用。通过在囊泡融合之前作用于突触囊泡启动来参与神经递质释放，并参与易释放囊泡池 (RRP) 的活性依赖性再填充。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备