产品
编 号:F083183
分子式:C15H10D3N3O2S
分子量:302.37
产品类型
结构图
CAS No: 1228182-47-5
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产品详情
生物活性:
Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
体外研究:
芬苯达唑d3 (20 μM; 48 小时) 逆转了 miR-143-5p 对增殖、集落形成能力和迁移的抑制作用。芬苯达唑d3 (20 μM; 48 小时) 可以提高 HIF-1α 和 GLUT1 的蛋白质表达水平。