产品
编 号：F759694
分子式：C6H10CuN6S2
分子量：293.86
分子式：C6H10CuN6S2
分子量：293.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
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询价
结构图
CAS No: 68341-14-0
产品详情
生物活性：
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent.
体内研究：
Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice.Animal Model:AD mice (K670N, M671L; 5-6 months old)
Dosage:10 mg/kg
Administration:Daily; p.o.
Result:Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.
体外研究：
Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%.
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent.
体内研究：
Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice.Animal Model:AD mice (K670N, M671L; 5-6 months old)
Dosage:10 mg/kg
Administration:Daily; p.o.
Result:Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.
体外研究：
Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%.
产品资料
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