产品
编 号：F759564
分子式：C16H17N3
分子量：251.33
分子式：C16H17N3
分子量：251.33
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 66529-17-7
产品详情
生物活性：
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.
体内研究：
Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats.Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags.Animal Model:290-450 g, Male Wistar rats
Dosage:3, 30 mg/kg
Administration:I.v.
Result:Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively.
Animal Model:Dogs
Dosage:0.2, 1, 2 mg/kg
Administration:Superior pancreaticoduodeneal artery infusion
Result:Reduced blood glucose levels by stimulating insulin release from the pancreatic islets.
体外研究：
Midaglizole stimulates insulin release with the EC50 values of 200 nM, 24 μM for rat islets and MIN6 β-cell line, respectively.
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.
体内研究：
Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats.Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags.Animal Model:290-450 g, Male Wistar rats
Dosage:3, 30 mg/kg
Administration:I.v.
Result:Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively.
Animal Model:Dogs
Dosage:0.2, 1, 2 mg/kg
Administration:Superior pancreaticoduodeneal artery infusion
Result:Reduced blood glucose levels by stimulating insulin release from the pancreatic islets.
体外研究：
Midaglizole stimulates insulin release with the EC50 values of 200 nM, 24 μM for rat islets and MIN6 β-cell line, respectively.
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