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编 号：F759497
分子式：C23H24O6
分子量：396.43
分子式：C23H24O6
分子量：396.43
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CAS No: 655237-16-4
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生物活性：
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes.
体内研究：
YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续。Animal Model:KK/Ay 2 diabetic mice
Dosage:0.1, 0.3, 1, and 3 mg/kg
Administration:oral administration
Result:Had a strong and sustained antihyperglycemic effect in both KK/Ay type 2 diabetic mice.
Animal Model:Male Sprague–Dawley rats
Dosage:1.0 and 3.0 mg/kg
Administration:intravenous injection (1.0 mg/kg) and oral administration (3.0 mg/kg)
Result:1.19 Administrationiv (1 mg/kg)po (3 mg/kg)
T1/2 (h)0.91.3
CLtot (L/h/kg)2483
Vdss (L/kg)3360
Cmax (ng/mL)101
Tmax (h)0.5
AUC0-inf (ng h/mL)403
F %29
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes.
体内研究：
YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续。Animal Model:KK/Ay 2 diabetic mice
Dosage:0.1, 0.3, 1, and 3 mg/kg
Administration:oral administration
Result:Had a strong and sustained antihyperglycemic effect in both KK/Ay type 2 diabetic mice.
Animal Model:Male Sprague–Dawley rats
Dosage:1.0 and 3.0 mg/kg
Administration:intravenous injection (1.0 mg/kg) and oral administration (3.0 mg/kg)
Result:1.19 Administrationiv (1 mg/kg)po (3 mg/kg)
T1/2 (h)0.91.3
CLtot (L/h/kg)2483
Vdss (L/kg)3360
Cmax (ng/mL)101
Tmax (h)0.5
AUC0-inf (ng h/mL)403
F %29
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