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编 号：F759392
分子式：C12H18N6O8
分子量：374.31
分子式：C12H18N6O8
分子量：374.31
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CAS No: 64038-56-8
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生物活性：
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma.
体内研究：
Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response and the maximum calcium response with an EC50 value of 16 μM in a subset of cells of cultured mouse DRG neurons and excites TRPA1 in rodent sensory neurons.Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 and 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical and cold allodynia in mice.Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice and antisense oligonucleotide for the TRPA1 receptor.Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists and antioxidants.Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model.Animal Model:C57BL/6, Trpa1+/+ or Trpa1?/?mice
Dosage:1 mg/kg
Administration:1 mg/kg, i.p. (for acute treatment);1 mg/kg, i.p.; 1, 3, 5 and 7 days (for chronic pain)
Result:Caused mechanical allodynia with acute or repeated administration.
体外研究：
Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC50 values of 50 and 10 μg/mL for T and B cells, respectively.Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC50 value of 23 μM and selectively activates the human TRPA1 channel.Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells.
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma.
体内研究：
Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response and the maximum calcium response with an EC50 value of 16 μM in a subset of cells of cultured mouse DRG neurons and excites TRPA1 in rodent sensory neurons.Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 and 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical and cold allodynia in mice.Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice and antisense oligonucleotide for the TRPA1 receptor.Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists and antioxidants.Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model.Animal Model:C57BL/6, Trpa1+/+ or Trpa1?/?mice
Dosage:1 mg/kg
Administration:1 mg/kg, i.p. (for acute treatment);1 mg/kg, i.p.; 1, 3, 5 and 7 days (for chronic pain)
Result:Caused mechanical allodynia with acute or repeated administration.
体外研究：
Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC50 values of 50 and 10 μg/mL for T and B cells, respectively.Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC50 value of 23 μM and selectively activates the human TRPA1 channel.Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells.
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