产品
编 号：F759171
分子式：C20H30N12O14P2
分子量：724.47
分子式：C20H30N12O14P2
分子量：724.47
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 609343-82-0
产品详情
生物活性：
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
体内研究：
Cyclic-di-GMP diammonium (100 μg/次；静脉注射；间隔 9 天的两次连续疫苗接种) 增强 TriVax 诱导的小鼠对黑色素瘤的免疫反应，并进一步增强 TriVax 的抗肿瘤作用。Animal Model:C57BL/6 (B6) mice (8- to 10-week-old).
Dosage:100 μg/per
Administration:Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax.
Result:Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 μg hgp100 or 100 μg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).Enhanced the anti-tumor activity of TriVax.
体外研究：
Cyclic-di-GMP diammonium (0.5-50 μM；5 days) 抑制人结肠癌细胞增殖。 Cyclic-di-GMP diammonium (0.5-50 μM；5天) 特异性提高 Jurkat 细胞中的 CD4 表达。 Cyclic-di-GMP diammonium (0.5-50 μM；5 天) 诱导 Jurkat 细胞周期停滞在 S 期细胞。
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
体内研究：
Cyclic-di-GMP diammonium (100 μg/次；静脉注射；间隔 9 天的两次连续疫苗接种) 增强 TriVax 诱导的小鼠对黑色素瘤的免疫反应，并进一步增强 TriVax 的抗肿瘤作用。Animal Model:C57BL/6 (B6) mice (8- to 10-week-old).
Dosage:100 μg/per
Administration:Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax.
Result:Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 μg hgp100 or 100 μg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).Enhanced the anti-tumor activity of TriVax.
体外研究：
Cyclic-di-GMP diammonium (0.5-50 μM；5 days) 抑制人结肠癌细胞增殖。 Cyclic-di-GMP diammonium (0.5-50 μM；5天) 特异性提高 Jurkat 细胞中的 CD4 表达。 Cyclic-di-GMP diammonium (0.5-50 μM；5 天) 诱导 Jurkat 细胞周期停滞在 S 期细胞。
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