产品
编 号：F758933
分子式：C33H36N3O7P
分子量：617.63
分子式：C33H36N3O7P
分子量：617.63
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CAS No: 564479-79-4
产品详情
生物活性：
RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM.
体内研究：
RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice.Animal Model:Male C57BL6/J mice
Dosage:0.9, 3, 10, and 30 mg/kg
Administration:Intravenous infuse for 30 minutes
Result:Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin.
体外研究：
RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE.
RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM.
体内研究：
RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice.Animal Model:Male C57BL6/J mice
Dosage:0.9, 3, 10, and 30 mg/kg
Administration:Intravenous infuse for 30 minutes
Result:Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin.
体外研究：
RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE.
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