产品
编 号:F758906
分子式:C25H24FN5O5S2
分子量:557.62
产品类型
结构图
CAS No: 560995-89-3
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产品详情
生物活性:
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .
体外研究:
PRRSV/CD163-IN-1 (Compound B7) (5 μM) inhibits theProtein-protein interaction (PPI) between PRRSV GP4 glycoprotein and CD163-SRCR5 domain.PRRSV/CD163-IN-1 (24 h) is well-tolerated by PAMs at concentrations below 25?μM, with the LC50 value of 81.7?μM.PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20?μM; 4 h) inhibits PRRSV infection of PAMs in a dose-dependent manner.PRRSV/CD163-IN-1 (15 μM) significantly inhibits the infection caused by both type I and type II PRRSV strains.