产品
编 号：F758817
分子式：C59H79N15O13
分子量：1206.35
分子式：C59H79N15O13
分子量：1206.35
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CAS No: 54784-44-0
产品详情
生物活性：
[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities.
体内研究：
[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats.[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity.[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old.[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone.Animal Model:Adult female Sprague-Dawley rats (200-250 g)
Dosage:1 mg/rat
Administration:SC injections, from 12:00 to 14:30 hr on the day of proestrus
Result:Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.
[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities.
体内研究：
[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats.[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity.[D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old.[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone.Animal Model:Adult female Sprague-Dawley rats (200-250 g)
Dosage:1 mg/rat
Administration:SC injections, from 12:00 to 14:30 hr on the day of proestrus
Result:Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.
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