产品
编 号：F758590
分子式：C18H20ClNO4
分子量：349.81
分子式：C18H20ClNO4
分子量：349.81
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CAS No: 5083-84-1
产品详情
生物活性：
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.
体内研究：
Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment.Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons.Animal Model:Male ICR mice (18–22 g)
Dosage:10~40 mg/kg
Administration:P.o.
Result:Significantly reduced the severity of joint swelling and erythema during the course of the experiment.
Animal Model:Female C57BL/6 mice (18–22 g)
Dosage:40 mg/kg
Administration:I.g.
Result:Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons.
体外研究：
Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31.Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia.Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia.Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia.
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.
体内研究：
Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment.Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons.Animal Model:Male ICR mice (18–22 g)
Dosage:10~40 mg/kg
Administration:P.o.
Result:Significantly reduced the severity of joint swelling and erythema during the course of the experiment.
Animal Model:Female C57BL/6 mice (18–22 g)
Dosage:40 mg/kg
Administration:I.g.
Result:Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons.
体外研究：
Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31.Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia.Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia.Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia.
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