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编 号:F758499
分子式:C117H181N34O32PS
分子量:2638.94
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Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .

体内研究:
Forigerimod (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬,使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷。Animal Model:MRL/lpr mice
Dosage:100 μg in 100 μL saline per mouse
Administration:Intravenous administration, single
Result:Corrected the cell content and distribution in MRL/lpr salivary glands.Corrected the defective of autophagy processes in SGs of MRL/lpr mice.
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