产品
编 号：F758435
分子式：C24H29ClN4O3
分子量：456.97
分子式：C24H29ClN4O3
分子量：456.97
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 478908-50-8
产品详情
生物活性：
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.
体内研究：
GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice.GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60%.Animal Model:MMTV-v-Ha-ras transgenic mice bearing mammary carcinoma
Dosage:100 mg/kg/day
Administration:S.c. with osmotic mini-pumps for 14 days
Result:Halted the tumors aggressive growth.Resulted in rapid tumor regression within 3 days of initiation of drug treatment.
体外研究：
GGTI-2154 inhibits the transfer of geranylgeranyl from [3H]GGPP to H-Ras CVLL, with an IC50 of 21 nM.
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.
体内研究：
GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice.GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60%.Animal Model:MMTV-v-Ha-ras transgenic mice bearing mammary carcinoma
Dosage:100 mg/kg/day
Administration:S.c. with osmotic mini-pumps for 14 days
Result:Halted the tumors aggressive growth.Resulted in rapid tumor regression within 3 days of initiation of drug treatment.
体外研究：
GGTI-2154 inhibits the transfer of geranylgeranyl from [3H]GGPP to H-Ras CVLL, with an IC50 of 21 nM.
产品资料
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