产品
编 号：F758378
分子式：C20H25NO2S2
分子量：375.55
分子式：C20H25NO2S2
分子量：375.55
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CAS No: 470454-73-0
产品详情
生物活性：
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment.
体内研究：
F 15845 (i.v.; 5 mg/kg) exhibits remarkable cardioprotective properties in anesthetized rat.Animal Model:Rat
Dosage:2.5 mg/kg, 5 mg/kg
Administration:intravenously
Result:Significantly reduced infarct size, decreased of troponin I levels and limited the long-term expansion of infarct size.
体外研究：
F 15845 (10 nM-10 μM) concentration-dependently reduces veratrine-induced diastolic contracture with an IC50 value of 0.14 μM in isolated atria.F 15845 (0.1-10 μM) preserves viability in isolated cardiomyocytes exposed to lysophosphatidylcholine (LPC).F 15845 (0.3 μM) significantly counteracts [Na+] increase during no-flow ischemia.F 15845 (0.3 μM, 0-35 min) delays the reduction in [Na+], but marks and maintains upon reperfusion.
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment.
体内研究：
F 15845 (i.v.; 5 mg/kg) exhibits remarkable cardioprotective properties in anesthetized rat.Animal Model:Rat
Dosage:2.5 mg/kg, 5 mg/kg
Administration:intravenously
Result:Significantly reduced infarct size, decreased of troponin I levels and limited the long-term expansion of infarct size.
体外研究：
F 15845 (10 nM-10 μM) concentration-dependently reduces veratrine-induced diastolic contracture with an IC50 value of 0.14 μM in isolated atria.F 15845 (0.1-10 μM) preserves viability in isolated cardiomyocytes exposed to lysophosphatidylcholine (LPC).F 15845 (0.3 μM) significantly counteracts [Na+] increase during no-flow ischemia.F 15845 (0.3 μM, 0-35 min) delays the reduction in [Na+], but marks and maintains upon reperfusion.
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