产品
编 号：F758353
分子式：C20H17FN4O
分子量：348.37
分子式：C20H17FN4O
分子量：348.37
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CAS No: 461449-78-5
产品详情
生物活性：
MRK-623 (Compound 14k) is an orally active, high-affinity GABAA receptor agonist, with the Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect.
体内研究：
MRK-623 (oral gavage; 0.3, 1, and 3 mg/kg; once) shows anxiolytic effects in the rat elevated plus maze assay.Animal Model:Rat
Dosage:0.3, 1, and 3 mg/kg
Administration:Oral gavage; 0.3, 1, and 3 mg/kg; once
Result:Showed 78% BZ site occupancy at 3 mg/kg, with an ID50 of 0.8 mg/kg.
体外研究：
MRK-623 shows efficacy at human GABAA receptor subtypes expressed in L(tk-) cells measured by whole cell patch-clamp electrophysiology.
MRK-623 (Compound 14k) is an orally active, high-affinity GABAA receptor agonist, with the Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect.
体内研究：
MRK-623 (oral gavage; 0.3, 1, and 3 mg/kg; once) shows anxiolytic effects in the rat elevated plus maze assay.Animal Model:Rat
Dosage:0.3, 1, and 3 mg/kg
Administration:Oral gavage; 0.3, 1, and 3 mg/kg; once
Result:Showed 78% BZ site occupancy at 3 mg/kg, with an ID50 of 0.8 mg/kg.
体外研究：
MRK-623 shows efficacy at human GABAA receptor subtypes expressed in L(tk-) cells measured by whole cell patch-clamp electrophysiology.
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