产品
编 号：F082316
分子式：C18H18F3NO
分子量：321.34
分子式：C18H18F3NO
分子量：321.34
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1227056-84-9
产品详情
生物活性：
Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.
体内研究：
Ampreloxetine (0.3, 1, 5, 10, 30, 60 mg/kg; p.o.; single dose) 在大鼠血浆中的 EC50 值分别为 11.7ng/mL 和 50.8ng/mL。Animal Model:Male Sprague Dawley rats
Dosage:0.3, 1, 5, 10, 30, 60 mg/kg
Administration:P.o.; single dose
Result:Showed good PK and PD parameter with Emax of 79%, 92% for SERT and NET, respectively; EC50 values of 50.8, 11.7 ng/mL for SERT, NET, respectively.
Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.
体内研究：
Ampreloxetine (0.3, 1, 5, 10, 30, 60 mg/kg; p.o.; single dose) 在大鼠血浆中的 EC50 值分别为 11.7ng/mL 和 50.8ng/mL。Animal Model:Male Sprague Dawley rats
Dosage:0.3, 1, 5, 10, 30, 60 mg/kg
Administration:P.o.; single dose
Result:Showed good PK and PD parameter with Emax of 79%, 92% for SERT and NET, respectively; EC50 values of 50.8, 11.7 ng/mL for SERT, NET, respectively.
产品资料
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