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编 号：F758281
分子式：C18H19ClN4
分子量：326.82
分子式：C18H19ClN4
分子量：326.82
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CAS No: 444724-92-9
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生物活性：
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia.
体内研究：
Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus).Animal Model:Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT).
Dosage:10 mg/kg
Administration:Intraperitoneal injection, single.
Result:Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia.
体内研究：
Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus).Animal Model:Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT).
Dosage:10 mg/kg
Administration:Intraperitoneal injection, single.
Result:Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
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