产品
编 号：F758178
分子式：C21H23N3O
分子量：333.43
分子式：C21H23N3O
分子量：333.43
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CAS No: 422554-29-8
产品详情
生物活性：
K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 μM) and MV-4-11 (IC50=10.4 μM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.
体外研究：
K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 μM) and MV-4-11 (IC50=10.4 μM) cells.K783-0308 (1, 3, 10, 30 μM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase.
K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 μM) and MV-4-11 (IC50=10.4 μM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.
体外研究：
K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 μM) and MV-4-11 (IC50=10.4 μM) cells.K783-0308 (1, 3, 10, 30 μM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase.
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