产品
编 号:F757980
分子式:C9H11N5O4
分子量:253.21
产品类型
结构图
CAS No: 38874-46-3
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产品详情
生物活性:
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction.
体外研究:
8-Azanebularine 修饰的 RNA 双链体 (0-3 μM) 可抑制 ADAR1 对 RNA 靶标的编辑 (例如 ADAR1 对 5-HT2C 和 NEIL1 的编辑)。