产品
编 号：F757956
分子式：C19H36N8O4
分子量：440.54
分子式：C19H36N8O4
分子量：440.54
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CAS No: 38482-71-2
产品详情
生物活性：
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
体内研究：
LH-RH (7-10) (i.v.) increases esterase activity in plasma kinin system in rats.LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein.Animal Model:New Zealand White Rabbit
Dosage:100, 500 and 2500 ng dissolved in 0-9% (w/v) NaCl solution and diluted
Administration:Ntracarotid infusion; infused with a constant volume of 7-5 mL per 30 min
Result:Caused LH release in the female rabbit during various reproductive conditions.
体外研究：
The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor).LH-RH (7-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 1.7 nM.
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
体内研究：
LH-RH (7-10) (i.v.) increases esterase activity in plasma kinin system in rats.LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein.Animal Model:New Zealand White Rabbit
Dosage:100, 500 and 2500 ng dissolved in 0-9% (w/v) NaCl solution and diluted
Administration:Ntracarotid infusion; infused with a constant volume of 7-5 mL per 30 min
Result:Caused LH release in the female rabbit during various reproductive conditions.
体外研究：
The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor).LH-RH (7-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 1.7 nM.
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