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编 号：F757856
分子式：C60H96N20O21S2
分子量：1497.66
分子式：C60H96N20O21S2
分子量：1497.66
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CAS No: 37293-17-7
产品详情
生物活性：
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis.
体内研究：
Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells.Animal Model:BALB/c nude mice with HT-29 or Hce-8693 cells
Dosage:10 or 15 mg/kg
Administration:Intraperitoneal injection; twice a week; 5 weeks
Result:Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.
Animal Model:BALB/c nude mice with CT-26 cells
Dosage:10 mg/kg
Administration:Intramuscular injection; every second day; 10 times
Result:Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
体外研究：
Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells.Boanmycin (6.7 μg/mL, 24 h) induces cell senescence.
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis.
体内研究：
Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells.Animal Model:BALB/c nude mice with HT-29 or Hce-8693 cells
Dosage:10 or 15 mg/kg
Administration:Intraperitoneal injection; twice a week; 5 weeks
Result:Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.
Animal Model:BALB/c nude mice with CT-26 cells
Dosage:10 mg/kg
Administration:Intramuscular injection; every second day; 10 times
Result:Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
体外研究：
Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells.Boanmycin (6.7 μg/mL, 24 h) induces cell senescence.
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