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编 号：F757636
分子式：C17H32N4O3
分子量：340.46
分子式：C17H32N4O3
分子量：340.46
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CAS No: 345267-14-3
产品详情
生物活性：
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model.
体内研究：
BCX-1898 (1, 10 mg/kg/天; 口服给药; 22 天) 以 10 mg/kg/天显示出对流感病毒的完全保护。 BCX-1898 (0.01, 0.1 mg/kg/天; 鼻内给药; 20 天) 表现出完全保护作用 (10 个模型中有 10 存活)。 Animal Model:Mice (13-18 g) infected with the A/Turkey/Mas/ 76 X A/Beijing/32/92 (H6N2) influenza virus
Dosage:1, 10 mg/kg/day
Administration:Oral; 22 days
Result:Showed complete protection against the influenza virus with 10 mg/kg/day, whereas at dose level (1 mg/kg/day) showed only a 10% protection against the influenza virus.
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model.
体内研究：
BCX-1898 (1, 10 mg/kg/天; 口服给药; 22 天) 以 10 mg/kg/天显示出对流感病毒的完全保护。 BCX-1898 (0.01, 0.1 mg/kg/天; 鼻内给药; 20 天) 表现出完全保护作用 (10 个模型中有 10 存活)。 Animal Model:Mice (13-18 g) infected with the A/Turkey/Mas/ 76 X A/Beijing/32/92 (H6N2) influenza virus
Dosage:1, 10 mg/kg/day
Administration:Oral; 22 days
Result:Showed complete protection against the influenza virus with 10 mg/kg/day, whereas at dose level (1 mg/kg/day) showed only a 10% protection against the influenza virus.
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