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编 号：F757547
分子量：6432
分子量：6432
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CAS No: 332437-00-0
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生物活性：
ODN?2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN?2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells.
体内研究：
ODN 2216 在小鼠疫苗接种模型中诱导 T 细胞介导的抗肿瘤免疫反应
体外研究：
ODN 2216 (6 μg/mL，9 天) 驱动幼稚 CD4 T 细胞的 Th1 发育。 ODN 2216 (2 μM，15 小时) 显著降低胸腺 DC 细胞凋亡。
ODN?2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN?2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells.
体内研究：
ODN 2216 在小鼠疫苗接种模型中诱导 T 细胞介导的抗肿瘤免疫反应
体外研究：
ODN 2216 (6 μg/mL，9 天) 驱动幼稚 CD4 T 细胞的 Th1 发育。 ODN 2216 (2 μM，15 小时) 显著降低胸腺 DC 细胞凋亡。
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