产品
编 号：F757482
分子式：C25H22N6O
分子量：422.48
分子式：C25H22N6O
分子量：422.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 326923-09-5
产品详情
生物活性：
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer.
体内研究：
1.19Pharmacokinetic Properties of JNJ-9350 in Mice . MicePO 10 mg/kg
Clearance (mL/min/kg) (Total/Unbound)73/5217
Volume of distribution (L/kg)1.7
Half-life (min)16
PPB (Mouse)98.6%
Oral F%34%
体外研究：
JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC50 values of 10 nM, 790 nM and ＞60 μM, respectively.JNJ-9350 (1.1-70 μM) binds with SMOX with a Ki value of 9.9 nM .
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer.
体内研究：
1.19Pharmacokinetic Properties of JNJ-9350 in Mice . MicePO 10 mg/kg
Clearance (mL/min/kg) (Total/Unbound)73/5217
Volume of distribution (L/kg)1.7
Half-life (min)16
PPB (Mouse)98.6%
Oral F%34%
体外研究：
JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC50 values of 10 nM, 790 nM and ＞60 μM, respectively.JNJ-9350 (1.1-70 μM) binds with SMOX with a Ki value of 9.9 nM .
产品资料
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