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编 号：F757275
分子式：C23H25N3O2
分子量：375.46
分子式：C23H25N3O2
分子量：375.46
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CAS No: 308088-10-0
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生物活性：
ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 μM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.
体内研究：
ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat.Animal Model:150-180 g male Sprague-Dawley rats
Dosage:50 mg/kg
Administration:I.p.
Result:Blocked acute tonic pain induced by formalin injection in the paw.
ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 μM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.
体内研究：
ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat.Animal Model:150-180 g male Sprague-Dawley rats
Dosage:50 mg/kg
Administration:I.p.
Result:Blocked acute tonic pain induced by formalin injection in the paw.
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