产品
编 号：F757122
分子式：C25H33Cl2N
分子量：418.44
分子式：C25H33Cl2N
分子量：418.44
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CAS No: 2962943-05-9
产品详情
生物活性：
OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models.
体内研究：
OY-201 (10-20 mg/kg, 腹腔注射) 减轻 MCAO 小鼠的脑损伤，并且与sertraline比显示出更高的安全性。Animal Model:Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)
Dosage:10 mg/kg and 20 mg/kg
Administration:IP
Result:Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg.
OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models.
体内研究：
OY-201 (10-20 mg/kg, 腹腔注射) 减轻 MCAO 小鼠的脑损伤，并且与sertraline比显示出更高的安全性。Animal Model:Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)
Dosage:10 mg/kg and 20 mg/kg
Administration:IP
Result:Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg.
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