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编 号：F757098
分子式：C25H20N4O2
分子量：408.45
分子式：C25H20N4O2
分子量：408.45
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CAS No: 2948304-00-3
产品详情
生物活性：
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research.
体内研究：
AMPK activator 11 (Compound 18a) (2.5 或 10 mg/kg 腹腔注射，持续 25 天) 选择性抑制 RKO 细胞体外异种肿瘤模型的肿瘤生长，且无毒性>。Animal Model:RKO cells related axenograft model on male BALB/nude mice
Dosage:2.5 or 10 mg/kg
Administration:Intraperitoneal injection (i.p.) for 25 days
Result:Resulted in 58.2% tumor growth inhibition, with no significant weight loss observed.Resulted in 77.1% inhibition of tumor growth but also caused a 36% weight loss. Immunohistochemistry results also showed activation of AMPK in tumor tissue.
体外研究：
AMPK activator 11 (Compound 18a) (0-30 μM；0-7 天) 抑制 CRC 细胞的生长和迁移，对其 IC50 值低于 1 μM。AMPK activator 11 (0-0.1 μM；24 小时) 显著提高 RKO 细胞的全局耗氧率 (OCR) ，同时细胞外酸化率 (ECAR) 轻微变化。AMPK activator 11 上调 p-AMPK 和线粒体复合物 III 和 V 的表达，并且具有在 CRC 中选择性激活 OXPHOS 的能力。
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) ( mitochondrial metabolism ) and can be used for anti-tumor and metabolic disease research.
体内研究：
AMPK activator 11 (Compound 18a) (2.5 或 10 mg/kg 腹腔注射，持续 25 天) 选择性抑制 RKO 细胞体外异种肿瘤模型的肿瘤生长，且无毒性>。Animal Model:RKO cells related axenograft model on male BALB/nude mice
Dosage:2.5 or 10 mg/kg
Administration:Intraperitoneal injection (i.p.) for 25 days
Result:Resulted in 58.2% tumor growth inhibition, with no significant weight loss observed.Resulted in 77.1% inhibition of tumor growth but also caused a 36% weight loss. Immunohistochemistry results also showed activation of AMPK in tumor tissue.
体外研究：
AMPK activator 11 (Compound 18a) (0-30 μM；0-7 天) 抑制 CRC 细胞的生长和迁移，对其 IC50 值低于 1 μM。AMPK activator 11 (0-0.1 μM；24 小时) 显著提高 RKO 细胞的全局耗氧率 (OCR) ，同时细胞外酸化率 (ECAR) 轻微变化。AMPK activator 11 上调 p-AMPK 和线粒体复合物 III 和 V 的表达，并且具有在 CRC 中选择性激活 OXPHOS 的能力。
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